حسب موقع ve3tro، قامت Capcom بإصدار المتطلبات الرسمية لتشغيل نسخة الحاسب الشخصي من Resident Evil 5 وهي :
Operating System
- Windows XP – Required
- Windows Vista – Recommended
Processor/CPU
- Intel PentiumD Processor / AMD Athlon64 X2 – Required
- Intel Core2Quad Processor or better / AMD Phenom X4 or better – Recommended
RAM
- Windows Vista (1GB) Windows XP (512MB) – Required
- Windows Vista (2GB or more) Windows XP (1GB or more) – Recommended
HDD
- 8.0GB or more
Monitor
- 800×600 – Required
- 1280×720 or larger – Recommended
Disc Drive
- DVD9 compatible drive
Graphics Card
- VRAM (256MB) – NVIDIA GeForce 6800 series / ATI Radeon HD 2400 Pro – Required
- VRAM (512MB) – NVIDIA GeForce 9800 series / ATI Radeon HD 4800 – Recommended
Sound Card
- Direct Sound Compatible (DirectX 9.0c or higher)
Interface
- Mouse & Keyboard – Required
- Gamepad – Recommended: Xbox360 Controller for Windows
Internet
- Broadband Connection – Recommended: For online modes
وذكر الموقع أيضا بأن اللعبة ستدعم يد تحكم Xbox 360 .
